Optimization and Engineering

Optimization of therapeutic antibody lead candidates is often required to improve and enhance their clinical profiles. With over a decade of experience affinity maturation programs completed and >96% success rate humanizing antibodies from a variety of species, including rabbit and chicken, IPA is the clear choice.

Animal-derived monoclonal antibodies can elicit human anti-animal antibody responses in patients. For that reason, it is often necessary to replace the animal-derived regions of the molecule with the corresponding human amino acid residues. You can depend on the robust and efficient antibody humanization services at IPA to retain affinity and specificity levels, consistently. Our approach is rooted in state-of-the-art in silico antibody modeling using our Artemis™ Intelligence Metadata (AIM)™ capabilities to identify essential framework and CDR residues for grafting onto a human antibody framework.

Antibody affinity is vital in therapeutic and diagnostic applications. The antibody affinity maturation service at IPA is designed to improve antibody affinities multiples times over. We apply different strategies to increase the affinity of your antibody, including gene shuffling and random mutagenesis.

Cloning and production of any variable antibody domain into any immunoglobulin context required, such as full-size mouse, rabbit, chicken, or human format, chimeras with any Fc region of choice, including effector mutants or Fc fusions.